Variants of Uncertain Significance

This video provides more information about variants of uncertain significance (VUS). Everyone has genetic variants. Some have the potential to impact our health and others do not. After a genetic variant is identified, the genetic testing laboratory determines how a variant impacts the structure and function of the gene and if there is a related health condition. Sometimes, there may not be enough information to determine whether a variant impacts health and disease. In these cases, the variant is classified as a VUS. Learn more about VUS and how additional information, including data shared by GenomeConnect participants, can increase understanding of VUS. To learn more about variant classification, see our variant classification overview video here:    • Variant Classification   To learn more about ClinVar and how to search this database, see our video about ClinVar here:    • How to Search ClinVar   To see other GenomeConnect videos about genetics concepts, view our playlist:    • GenomeConnect and Patient Data Sharing