REM Sleep Behavior Disorder: How does Parkinson pathology evolve? S5 - Ep5

Probably the most concerning aspect of REM sleep behavior disorder is that it is often a prodrome for Parkinson's disease and other related conditions. In this podcast we explore current concepts of how dream enactment behaviors can progress to serious neurodegenerative disorders. 00:39 How does a sleep disorder evolve into a broader neurodegenerative disease? (With guest introduction: Dr. Bradley Boeve) 01:26 Understanding Synucleinopathies 03:22 The Braak Hypothesis 7:01 Explanation of protein misfolding 9:10 Emphasize that there is no evidence that Parkinson's disease and related conditions are infectious 9:44 Challenges to the Hypothesis 13:18 - Conclusion and Sign-off From Mayo Clinic to your inbox, sign-up for free: https://mayocl.in/3e71zfi Visit Mayo Clinic: https://mayocl.in/2COVmlm Like Mayo Clinic on Facebook:   / mayoclinic   Follow Mayo Clinic on Instagram:   / mayoclinic   Follow Mayo Clinic on X, formerly Twitter: https://x.com/MayoClinic Follow Mayo Clinic on Threads: https://www.threads.net/@mayoclinic