[Alex Wiesman] Neurochemistry shapes brain signaling in healthy and pathological aging

SFU's Neuroscience and Neurotechnology Seminar Series September 25, 2025 Speaker: Dr. Alex Wiesman, Simon Fraser University Dr. Wiesman is an Assistant Professor in the Department of Biomedical Physiology & Kinesiology and Scientific Director of ImageTech Lab at Simon Fraser University. His research is focused on how neuromodulatory systems disrupt brain signaling in Parkinson's and Alzheimer's disease to identify prognostic markers and clinical intervention targets. Dr. Wiesman is introduced by Dr. Lisa Julian, Assistant Professor in the Department of Molecular Biology and Biochemistry. ~~~~~~~~~~~~~~~~~~~~~~~~~~~ Video Content: 0:00:00 - Introduction, Lisa Julian 0:01:57 - Neurochemistry shapes brain signaling, Alex Wiesman 0:09:35 - Traditional approaches to brain mapping 0:14:22 - Topographical analysis for studying the whole brain 0:20:30 - Use Case 1: Neurochemical “enrichment” in neurodegenerative disorders 0:29:04 - Use Case 2: Degeneration of brain nuclei in Parkinson's disease 0:34:41 - Use Case 3: Neurochemical atlas “searches” to uncover new patterns 0:40:50 - What’s next 0:46:38 - Acknowledgements 0:47:33 - Closing Remarks, Lisa Julian