What It's Like To Fight Every Immune Cell

Never thought I'd feel bad for a bacteria... Thanks for watching! 00:00 - Let's fight! 00:10 - Neutrophil 01:26 - Basophil 02:34 - Eosinophil 03:33 - Dendritic Cell 04:16 - B Cell 05:37 - Helper T Cell and Killer T Cell 06:56 - Natural Killer Cell 07:50 - Macrophage 08:42 - Regulatory T Cell -------- SOURCES 1. NEUTROPHIL "Neutrophils in chronic inflammatory diseases" — Cellular & Molecular Immunology, 2022 "Neutrophil diversity and function in health and disease" — Signal Transduction and Targeted Therapy, 2024 "In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days" — Blood, 2010 "The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function" — Frontiers in Immunology, 2018 "Neutrophil Extracellular Traps Kill Bacteria" — Science, 2004 "Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity" — Advanced Science, 2024 2. BASOPHIL & MAST CELL "Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test" — Allergy, 2024 "Basophils are important for development of allergic skin inflammation" — Journal of Allergy and Clinical Immunology, 2024 "Basophils and mast cells in immunity and inflammation" — Seminars in Immunopathology, 2016 "Basophils beyond allergic and parasitic diseases" — Frontiers in Immunology, 2023 "Histology, Mast Cells" — StatPearls (NIH) 3. EOSINOPHIL "In situ crystalline structure of the human eosinophil major basic protein-1" — bioRxiv, 2024 "Physiology, Major Basic Protein" — StatPearls (NIH) "Eosinophils as modulators of host defense during parasitic infection" — Journal of Leukocyte Biology, 2024 "Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis" — PLOS Neglected Tropical Diseases "Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA" — Cell Reports, 2024 4. DENDRITIC CELL "Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses" — Cellular & Molecular Immunology (Nature), 2020 "Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense" — Cell, 2025 "Podosomes of dendritic cells facilitate antigen sampling" — Journal of Cell Science "The role of cDC1s in vivo: CD8 T cell priming through cross-presentation" — PMC 5. B CELL "Antibody structure and function: the basis for engineering therapeutics" — Antibodies (MDPI), 2023 "Germinal Centers" — Annual Review of Immunology, 2022 "Germinal Center B Cell Dynamics" — Immunity, 2016 "The generation of antibody-secreting plasma cells" — Nature Reviews Immunology, 2015 "Commonality despite exceptional diversity in the baseline human antibody repertoire" — Nature, 2019 "Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination" — Frontiers in Immunology, 2019 "B cell memory: building two walls of protection against pathogens" — Nature Reviews Immunology, 2020 6. HELPER T CELL (CD4) "CD4 T Helper Cell Subsets and Related Human Immunological Disorders" — PMC, 2020 "Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses" — Cellular & Molecular Immunology (Nature), 2020 7. KILLER T CELL (CD8) "Perforin and granzymes: function, dysfunction and human pathology" — Nature Reviews Immunology, 2015 "Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack" — Blood, 2013 "Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity" — Nature Communications, 2021 "Understanding serial killers" — Nature Immunology, 2023 8. NATURAL KILLER (NK) CELL "The dynamic life of natural killer cells" — Immunology & Cell Biology, 2004 "A new self: MHC-class-I-independent Natural-killer-cell self-tolerance" — Nature Reviews Immunology "Human NK Cell Education by Inhibitory Receptors for MHC Class I" — Immunity "In vivo kinetics of human natural killer cells" — Blood, 2007 "Immune memory redefined: characterizing the longevity of natural killer cells" — PMC, 2010 9. MACROPHAGE "Monocyte and macrophage differentiation" — Biomarker Research, 2014 "Monocyte differentiation and antigen-presenting functions" — Nature Reviews Immunology, 2017 "Measuring Opsonic Phagocytosis via Fcγ Receptors and Complement Receptors on Macrophages" — PMC, 2012 "Tissue-specific expression of IgG receptors by human macrophages ex vivo" — PMC, 2019 10. REGULATORY T CELL (Treg) "How regulatory T cells work" — Nature Reviews Immunology, 2008 "The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases" — PMC, 2024 "Regulatory CD4+ T cells: permanent or temporary suppressors of immunity" — PMC, 2024