HiRO Knowledge Translation Rounds | Polygenic Risk Scores in Cardiogenetics | May 4th, 2026

Welcome to the HiRO Knowledge Translation Rounds, hosted by Dr. Simon Hansom and Dr. David Lee. In this session, trainees and clinicians in cardiogenetics explore how polygenic and monogenic genetic risk can shape atrial fibrillation and cardiomyopathy, with three presentations examining new approaches to understanding disease susceptibility and phenotype. 0:00 - Introduction 1:53 - 🫀 Saif F. Dababneh – Polygenic Risk of New Onset Atrial Fibrillation in Nonischemic Cardiomyopathy Explore how polygenic risk scores may improve prediction of new-onset atrial fibrillation in patients with nonischemic cardiomyopathy, and how combining genetic and clinical risk factors could strengthen AF risk stratification. 19:28 - 🫀 Dr. Sina Safabakhsh – Polygenic and Monogenic Contributions to Tachycardia-Associated Cardiomyopathy An exploration of the genetic factors underlying tachycardia-associated cardiomyopathy, including the potential contributions of both common polygenic risk and rare monogenic variation to susceptibility to this condition. 39:27 - 🫀 Dr. Guilherme L. da Rocha – Cardiomyopathy Gene Variants and Polygenic Risk Scores in Atrial Fibrillation: Evidence for an Atrial-First Phenotype Dr. Rocha examines how cardiomyopathy-related genetic variants can increase the risk of atrial fibrillation, even before clear signs of cardiomyopathy or heart failure appear, and how polygenic risk scores may help show whether someone is more likely to develop atrial or ventricular disease. Learn More About HiRO: https://hiro.heartsinrhythm.ca/