MPNST in NF1: Tumor Progression, Diagnosis and Treatment | Dr. Bornhorst

How can a plexiform neurofibroma progress toward malignant peripheral nerve sheath tumor (MPNST) in neurofibromatosis type 1 (NF1)? Dr. Miriam Bornhorst explains tumor progression, atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP), and MPNST. Topics include genetic changes within tumors, pain and rapid growth, MRI and PET imaging, biopsy, and treatment approaches. Dr. Bornhorst also reviews plexiform neurofibroma treatment options, including MEK inhibitors, alongside surgery, radiation, chemotherapy, and clinical-trial approaches for more aggressive tumors. Whether you are living with NF1, supporting a family member, or learning about neurofibromatosis, this segment offers information to help you better understand NF1-associated tumors and prepare for conversations with your healthcare team. Subscribe to NF Midwest for more neurofibromatosis education, expert presentations, and community conversations. Share this video with someone who could benefit from learning more about NF1 care. This segment is part of NF Midwest’s Virtual Power Hour, Tumors in NF1, with Dr. Miriam Bornhorst. Thank you to SpringWorks for sponsoring this NF Midwest Power Hour. Information reflects what was available at the time of recording. Research, treatments, and care recommendations may have changed. ABOUT NF MIDWEST Since 1981, NF Midwest has connected children, adults, and families affected by neurofibromatosis (NF) and schwannomatosis with education, resources, and a supportive community. Serving Illinois, Indiana, Iowa, Kentucky, Missouri, and Wisconsin, NF Midwest helps ensure no one faces NF alone. Learn more and connect: NF Midwest: https://www.nfmidwest.org/ 2027 iNFo Fair: https://www.nfmidwest.org/care-progra... Power Hours: https://www.nfmidwest.org/care-progra... Education & Support: https://www.nfmidwest.org/care-progra... Free Packet of iNFo: https://www.nfmidwest.org/care-progra... Donate: https://give.nfmidwest.org/campaign/6... Contact us: https://www.nfmidwest.org/about/conta... This video is for educational purposes only and does not replace medical advice. Please discuss personal health questions and care decisions with a qualified healthcare professional. #NF1 #MPNST #PlexiformNeurofibromas #ANNUBP #NFMidwest