Aspergillosis Explained | Pathogenesis, Clinical Features, Lab Diagnosis & Treatment | MBBS Micro

NOTES : https://drive.google.com/file/d/13o4A... This lecture covers Aspergillosis, caused by fungi of the genus Aspergillus, an important cause of opportunistic fungal infections in clinical practice. The video explains pathogenesis, clinical manifestations, laboratory diagnosis, and treatment of aspergillosis in a clear and exam-oriented manner. 🔹 Topics Covered in This Lecture 1️⃣ Introduction Caused by Aspergillus species (e.g., A. fumigatus) Ubiquitous mold found in environment Opportunistic pathogen Infection via inhalation of spores 2️⃣ Pathogenesis Inhaled conidia reach lungs Germination into hyphae Host immune response determines disease type Angioinvasion in invasive forms 3️⃣ Clinical Manifestations 📌 Allergic form: ABPA (Allergic bronchopulmonary aspergillosis) 📌 Colonizing form: Aspergilloma (fungus ball in lung cavity) 📌 Invasive form: Seen in immunocompromised patients Can involve lungs, brain, and other organs 4️⃣ Laboratory Diagnosis KOH mount → septate hyphae Acute angle (~45°) branching Culture on Sabouraud agar Galactomannan antigen test Imaging (fungus ball in cavity) 5️⃣ Treatment Voriconazole (drug of choice) Amphotericin B (alternative) Surgical removal (aspergilloma in some cases) 🎓 Ideal For ✔ MBBS students ✔ NEET PG / NEXT aspirants ✔ USMLE / FMGE preparation ✔ Rapid microbiology revision 🔔 Subscribe for more Microbiology Quick Revision | Exam-Focused Learning