Drug Receptor Complex | Mechanism of Competitive Antagonist | Drug + Receptor Complex | Receptors

Pharmacology- Pharmacology is made up of two main words- ‘Pharma’ + ‘Logy’ in some books there is Pharmakon in the place of Pharma, but to make you better understand we have made little changes. Pharma is related to drug or medicine and logy means- to study. So if we merge these two words together, this will become- PHARMACOLOGY. Pharmacodynamic- Pharmacodynamic is a study of drug’s effect on body, so we can say it’s a study of- what does DRUG do to the BODY. Let’s illustrate it in a very easy language. Pharmacokinetic- “What does BODY do to the DRUG ” we have simple interchanged the BODY and DRUG to make a definition. And as per the definition, our body responds to any drug by giving ADME effects. A stands for - Absorption D stands for - Distribution M stands for - Metabolism E Stands for- Excretion Some drugs modulate the opening and closing of the channels. Example- (1) Quinidine blocks myocardial Na+ channels (2) Nicorandil opens ATP sensitive K+ channels. (3) Nifedipine block L-Type of voltage-sensitive Ca2+ channel. (4) Phenytoin modulates voltage-sensitive neuronal Na+ channel. (5) Ethosuximide inhibits T type of Ca2+ channels in the thalamic neuron. Receptors are the macromolecule or binding site located on the surface or inside the effector cell that serves to recognize the signal molecule or drug and initiate the response to it, but they don’t have other functions. The largest number of drug that does not bind directly to the effectors like- Enzyme, Channels, Transporter structural protein, template biomolecule but act through specific regulatory macromolecule or the site on them which bind and interact with the drugs are called “Receptor” Few Basic terms related to receptor and drug-receptor complex (1) Agonist- Agonist is the agent which activates the receptor to produce an effect similar to the of the physiological signal molecule (2) Antagonist- Antagonists are agent which prevent the action of agonist on a receptor or the subsequent response but does not have any effect of its own (3) Inverse Agonist- Inverse Agonist is the agents which activate a receptor to produce an effect in the opposite direction to that of the agonist (4) Partial Agonist- An agent who activates receptors to produce a submaximal effect but antagonize the effect of a full agonist. Get in touch with the solution by just clicking following links- Facebook Group-   / solutionpharamcy   Facebook Page-   / pharmavideo   New channel (Pharmacy Dictionary) -    / @pharmacydictionary   Instagram-   / solutionpharmacy   E-Mail for official and other work - solutionpharmacy@gmail.com LinkedIn-   / pushpendrakpatel   #solutionpharmacy #Pharmacologyclass #GPATonlinetest