Every Methyl Counts: Folate, Choline and the Science of Methylation

What if the nutrients we consume can influence not our genetic code itself, but how our bodies read and use it? In this episode of Supplement Source, host Jeff Ventura explores the emerging science of epigenetics, methylation and cellular health with Lauren Eisen and Eric Ciappio of Balchem, along with expert Emily Ho. The conversation breaks down the complex science of methylation in accessible terms, including how epigenetic mechanisms help regulate which genetic information cells use and how nutrients can contribute to those processes. The guests discuss the importance of methylation during pregnancy and early development, while also examining its relevance throughout the lifespan and to healthy aging.   The discussion also explores the roles of folate and choline as sources of methyl groups, the differences between folic acid and methylfolate, nutrient intake gaps, and why interest in methylation could create new opportunities for supplement brands to communicate the science of cellular nutrition beyond the traditional prenatal category.   The takeaway: genetics may provide the blueprint, but nutrition is part of the complex biological machinery involved in how that blueprint is used. About the Council for Responsible Nutrition (CRN)  The Council for Responsible Nutrition (CRN), founded in 1973 and based in Washington, D.C., is the leading trade association representing the dietary supplement and functional food industry. Bringing together manufacturers, ingredient suppliers, and service providers, CRN unites its member companies around a shared commitment to science, transparency, and responsible business practices—advancing a strong, credible marketplace that supports consumer health and industry growth. In an increasingly complex regulatory and media environment, CRN serves as the industry’s front line—shaping science-based policy, defending market access, and countering misinformation. Through strategic advocacy, self-regulatory leadership, voluntary guidelines, and evidence-based communications, CRN ensures that responsible companies are recognized, protected, and positioned to innovate and compete. Learn more at crnusa.org and follow @CRN_Supplements on X and LinkedIn.