Alzheimer’s Diagnostics: The Critical Role of Specimen Quality, Longitudinality & Data Depth

Accurate research relies on the quality and relevance of biospecimens that are utilized. Using Alzheimer’s disease (AD) as an example, Dr. Cathie Miller will discuss how a foundation of high-quality, rigorously characterized biospecimens are building the future of AD diagnostics. The current AD diagnostic revolution relies on accessible blood-based biomarkers like pTau217 and pTau181 to bridge the global detection gap. However, valid clinical implementation demands more than just new assays. Success hinges on three pillars: pre-analytical rigor to ensure biomarker stability, longitudinal tracking to map disease progression, and comprehensive metadata to address health disparities. Progress can be accelerated by integrating matched plasma-CSF sets and multi-timepoint collections that track donors over years. Furthermore, ethnically diverse cohorts and strictly controlled raw materials enable researchers to harmonize assays, validate clinical cutoffs, and ensure diagnostics work for all populations. These specialized resources provide the essential infrastructure to transform promising biomarkers into widely available diagnostic tools. Download the slides: https://bioivt.com/educational-conten... Additional resources on this topic: https://bioivt.com/resources/educatio... Questions, comments and requests: https://bioivt.com/about/contact-us Access BioIVT's biospecimens: https://bioivt.com/products Other previously aired webinars: https://bioivt.com/educational-conten...) Upcoming webinar notifications: https://bioivt.com/resources/newslett... About the presenter Cathie Miller, PhD, is Senior Director of Product Management at BioIVT, which enables smarter science and accelerates medical breakthroughs by delivering high-quality personalized biospecimen solutions and research services to the life science and diagnostic industries. Dr. Miller has more than 20 years of experience as a bench scientist, director, and global product manager, focused on using biospecimens to advance cancer, immunology and virology research.