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What is the main cause of Ankylosing spondylitis? Ankylosing spondylitis - Symptoms & causes - Mayo Clinic Ankylosing spondylitis has no known cause, though genetic factors seem to be involved. In particular, people with a gene called HLA-B27 are at a greatly increased risk of developing ankylosing spondylitis. However, only some people with the gene develop the condition. Girivardhan Herbs By - La-Lateesh Dr . Latish Chakole Bone Setting ( Chiropractic ) Facebook -   / girivardhanherbs   Instagram -   / girivardhanherbs   📍Nagpur, Maharashtra • Treatment For Migraine, Diabetes, Arthritis, Slipped Disc • Contact - 8928219532 • Address - Bhawani Nagar, Pardi, Nagpur