Understanding Prep, PEP, and DoxyPEP for HIV and STIs

PrEP vs PEP vs DoxyPEP: What They Do, How to Take Them, and Common Mistakes https://isprepforme.com/prep-vs-pep-v... Dr. George Forgan Smith, a Melbourne GP with specialist training in HIV and sexual health, explains the key differences between PrEP, PEP, and DoxyPEP and addresses common confusion. PrEP prevents HIV only and can be taken as daily tablets, on-demand tablets, or via injectable options (cabotegravir every 2 months or lenacapavir every 6 months, noting these injections aren’t funded in Australia). PEP is urgent “rescue” treatment to prevent HIV after significant exposure and must be started within 72 hours, taken for at least 28 days; people who’ve needed PEP may be good candidates for PrEP. DoxyPEP is doxycycline 200 mg taken within 72 hours after sex to reduce bacterial STIs—especially chlamydia and syphilis (less effective for gonorrhea)—and does not protect against HIV; regular screening and discussing options with a sexual health-focused doctor are recommended. 00:00 PrEP vs DoxyPEP Intro 00:28 PrEP Options Explained 01:24 What PrEP Does Not Do 01:38 PEP After Exposure Basics 02:37 PEP Timing and Urgency 03:16 DoxyPEP What It Is 03:53 How to Take DoxyPEP 04:27 Common DoxyPEP Mistakes 05:19 Screening and Side Effects 06:16 PrEP Side Effects and Kidneys 07:37 Talking to Your Doctor 08:48 Final Recap and Resources