Medications for Restless Legs Syndrome (part 1) | Scientific Background & Medication Options

This video explains the scientific background of Restless legs syndrome as well as the different classes of medications used to treat it. 00:00 Intro 0:57 Disclaimer 2:03 Scientific background 7:05 Augmentation 11:56 Medications 12:34 Iron 16:53 Levodopa 18:27 Dopamine agonists 21:37 A2Ds 23:16 Other meds 24:37 Opioids My video links: Iron & B12:    • Tips for taking iron and B12 supplements w...   First RLS video:    • Restless Legs Syndrome and how to manage i...   References: Guo S, Huang J, Jiang H, Han C, Li J, Xu X, Zhang G, Lin Z, Xiong N, Wang T (2017) Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management. Front Aging Neurosci. 2(9):171. https://www.ncbi.nlm.nih.gov/pmc/arti... * Paulus W, Trenkwalder C (2006) Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome. Lancet Neurol. 5(10):878-86. https://pubmed.ncbi.nlm.nih.gov/16987... Note from Jill: this is a very technical article, but interesting for those with a scientific background who would like to know more about the biology of RLS. Not free to access unfortunately. * Silber MH, Buchfuhrer MJ, Earley CJ, Koo BB, Manconi M, Winkelman JW (2021) Scientific and Medical Advisory Board of the Restless Legs Syndrome Foundation. The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clin Proc. 96(7):1921-1937. https://www.mayoclinicproceedings.org... Note from Jill: this is a guide to treating RLS for clinicians, but it's fairly easy for the layman to understand, and free to access. If you'd like to learn more about RLS, I'd recommend this article. It's a good one to share with your GP/PCP too. * Silber MH, Becker PM, Buchfuhrer MJ, Earley CJ, Ondo WG, Walters AS, Winkelman JW (2018) Scientific and Medical Advisory Board, Restless Legs Syndrome Foundation. The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome. Mayo Clin Proc. 93(1):59-67. https://www.mayoclinicproceedings.org... * Trenkwalder C, Allen R, Högl B, Clemens S, Patton S, Schormair B, Winkelmann J (2018) Comorbidities, treatment, and pathophysiology in restless legs syndrome. Lancet Neurol. 17(11):994-1005. https://pubmed.ncbi.nlm.nih.gov/30244... * Vlasie, A., Trifu, S.C., Lupuleac, C., Kohn, B., & Cristea, M.B. (2022). Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches (Review). Experimental and Therapeutic Medicine, 23, 185. https://www.spandidos-publications.co... * Winkelman JW (2022) Treating Severe Refractory and Augmented Restless Legs Syndrome. Chest. 162(3):693-700. https://www.sciencedirect.com/science... Copyright Arrow PNGs by Vecteezy "https://www.vecteezy.com/free-png/arrow"