College Football Week 5 Preview: Alabama vs Miss State, Florida vs Missouri, OSU vs Iowa

Joe DeLeone and Blake Ruffino share their College Football Week 5 preview, breaking down Ohio State vs Iowa, Mississippi State vs Alabama and Florida vs Missouri. They examine the biggest matchups, keys to victory and questions facing six programs in the 2026 SEC and Big Ten football races. Ohio State, Alabama and Florida each face a road challenge, while unbeaten Iowa and Mississippi State have opportunities to make major statements. Joe and Blake discuss which strengths can travel, where each opponent can create problems and what these games could mean for the College Football Playoff picture. Ohio State vs Iowa: Can Julian Sayin and Jeremiah Smith keep the Ohio State Buckeyes offense rolling against an Iowa Hawkeyes team coming off a dramatic 20-19 win over Michigan? The Ohio State football preview examines Iowa’s 4-0 start, the challenge in Iowa City and the matchups that could decide this Big Ten showdown. Mississippi State vs Alabama: Kamario Taylor and Mississippi State football enter unbeaten after a 31-24 victory over Missouri. Joe and Blake assess the Bulldogs’ explosive offense, Keelon Russell and Alabama football, and what each team must do to control this SEC matchup in Starkville. Florida vs Missouri: Jon Sumrall, Jadan Baugh and Florida football head to Columbia after the Gators’ 52-28 statement win over Ole Miss. Can Missouri football respond to its Mississippi State loss and slow Florida’s rushing attack, or will the Gators keep building momentum? This episode covers College Football Week 5 matchups, Ohio State vs Iowa analysis, Alabama vs Mississippi State, Florida vs Mizzou and SEC and Big Ten contenders. Share your winners in the comments and subscribe for more college football previews and reactions. #CollegeFootball #CFB #CollegeFootballWeek5 #OhioStateFootball #IowaFootball #AlabamaFootball #MississippiStateFootball #FloridaFootball #MizzouFootball #SECFootball #BigTenFootball #CollegeFootballPlayoff Sign up for a Kalshi account and use promo code RJS: http://kalshi.com/r/RJS #kalshipartner (0:00) Introduction (11:10) Alabama Mississippi State (34:13) Ohio State Iowa (49:45) Florida vs Missouri