Can Louisville SHOCK Ole Miss? | Louisville vs. Ole Miss Preview

Louisville Football is officially BACK, and the Cardinals aren't getting an easy start to the 2026 season. Louisville heads to Nashville for a HUGE Week 1 matchup against No. 9 Ole Miss in a game that could tell us a lot about just how good this Cardinals team really is. In this video, I break down Louisville vs. Ole Miss from both sides of the ball and look at the biggest matchups that could ultimately decide this game. Can Louisville's defense slow down Trinidad Chambliss and Kewan Lacy? Can Clev Lubin and the Cardinals' defensive front take advantage of a rebuilt Ole Miss offensive line? And on the other side, can Lincoln Kienholz, Isaac Brown and Jeff Brohm's offense find success against Pete Golding's defense? Louisville enters this season with legitimate ACC Championship and College Football Playoff expectations. Now it's time to see what they're made of. Can Louisville pull off the upset in Nashville? Let me know your score prediction in the comments! 🔴 SUBSCRIBE for more Louisville Football & Basketball coverage 👍 LIKE the video if you enjoyed 🔔 Turn on notifications so you don't miss future Louisville Sports Talk videos #LouisvilleFootball #GoCards #Louisville #OleMiss #CollegeFootball #CFB