Biochemistry of blood sugar regulation & glucose homeostasis

The mechanisms are complicated, but the logic is simple. Here's how they intertwine. When it comes to glycogen breakdown (glycogenolysis), your liver and muscle have different priorities… liver’s gotta glucose-deliver glycogenolysis → glucose 6-phosphate → glucose → ship out muscle says, glucose is “mine!” glycogenolysis → glucose 6-phosphate → glycolysis → ATP YouTube:    • Glycogen metabolism (glycogenesis & glycog...   Blog: http://bit.ly/metabolismglycolysis Metabolism spreadsheet: https://bit.ly/metabolism_spreadsheet Insulin & glucagon are hormonal “opposites” that work to control blood sugar & anabolism vs. catabolism Glucagon says “α-ll” the glucose is gone secreted by pancreatic α cells in response to low blood sugar stimulates catabolic processes stimulates liver to make & ship out glucose acts largely through PKA (aka cAMP-dependent protein kinase) signaling Insulin says β-etter let some glucose in! secreted by pancreatic β cells in response to high blood sugar stimulates anabolic processes stimulates liver to take in & store glucose acts largely through PKB (Akt) signaling more on the regulation: YouTube:    • Glycogen metabolism (glycogenesis & glycog...   Blog: http://bit.ly/metabolismglycolysis more on all sorts of metabolic stuff: http://bit.ly/metabolismglycolysis &    • Logic of metabolic "pathways" - starring g...      302 Sp24 course videos:    • Biochemistry 302 Spring 2024 Course Videos         more about all sorts of things: #365DaysOfScience All (with topics listed) 👉 http://bit.ly/2OllAB0 or search blog: http://thebumblingbiochemist.com                      #scicomm #biochemistry #molecularbiology #biology #sciencelife #science #realtimechem   Further reading: Chandel N. S. (2021). Carbohydrate Metabolism. Cold Spring Harbor perspectives in biology, 13(1), a040568. https://doi.org/10.1101/cshperspect.a... https://bio.libretexts.org/Bookshelve... https://bio.libretexts.org/Bookshelve... https://bio.libretexts.org/Bookshelve... Meyer, C., Dostou, J. M., Welle, S., & Gerich, J. E. (2002). Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. American Journal of Physiology-Endocrinology and Metabolism, 282(2), E419-E427. https://doi.org/10.1152/ajpendo.00032... Alsahli, M., Shrayyef, M., & Gerich, J. E. (2017). Normal glucose homeostasis. Principles of Diabetes Mellitus, 1-20. https://doi.org/10.1007/978-3-319-207... (2016). Principles of diabetes mellitus.. https://doi.org/10.1007/978-3-319-207... Woerle, H. J., Meyer, C., Dostou, J. M., Gosmanov, N. R., Islam, N., Popa, E., Wittlin, S. D., Welle, S. L., & Gerich, J. E. (2003). Pathways for glucose disposal after meal ingestion in humans. American journal of physiology. Endocrinology and metabolism, 284(4), E716–E725. https://doi.org/10.1152/ajpendo.00365...