BDS 2nd Year Pathology | Cell death / Apoptosis | Most Wanted Series | Dr Anusha Rathi | One Shot

BDS 2nd Year Pathology | Cell death / Apoptosis | Most Wanted Series | Dr Anusha Rathi | One Shot Download the free notes and pdf related to this lecture from PW MedEd BDS Telegram Channel 👇 https://t.me/PWMedEd_BDS _______________________________________ Welcome back to the Most Wanted Series! In this highly informative One Shot session, Dr Anusha Rathi simplifies one of the most fundamental and heavily tested topics in General Pathology: Cell Death and Apoptosis. Apoptosis or programmed cell death is a guaranteed long note or short note question in BDS 2nd Year and MBBS university exams. Understanding the delicate balance of cellular survival and destruction is also crucial for competitive exams. Dr Anusha breaks down the pathways, molecular mechanisms, and structural changes into easy to memorize concepts and flowcharts. In this video, we cover: Introduction to Cell Death Differentiating between reversible cell injury and irreversible cell injury Overview of the two main types of cell death which are Necrosis and Apoptosis Definition and Examples of Apoptosis Why it is called programmed cell death or cellular suicide Physiological examples like embryogenesis and endometrial breakdown Pathological examples like viral infections and radiation induced DNA damage Morphological Changes Distinct microscopic features including cell shrinkage and chromatin condensation Formation of apoptotic bodies and intact cell membranes without inflammation Molecular Mechanisms of Apoptosis The Initiation Phase: Understanding the Intrinsic Mitochondrial Pathway and the role of Cytochrome c release The role of the Bcl 2 family of proteins covering pro apoptotic members like Bax and Bak versus anti apoptotic members like Bcl 2 and Bcl xL The Extrinsic Death Receptor Pathway involving Fas and TNF receptors The Execution Phase: Activation of the Caspase cascade including initiator caspases and executioner caspases Clearance of Apoptotic Cells How phagocytes recognize eat me signals like phosphatidylserine on the outer membrane flip High-Yield Comparison: Apoptosis versus Necrosis A comprehensive comparison highlighting differences in cell size, membrane integrity, inflammation, and energy requirements Timestamps : 00:00 Introduction to Apoptosis in Pathology 05:02 Apoptosis as Physiological and Pathological Cell Death 09:34 Key Pathways of Apoptosis – Intrinsic and Extrinsic 14:33 Meaning of Apoptosis – Falling Off into Apoptotic Bodies 20:49 Extrinsic Pathway – Fas, CD95 and Death Receptors 27:36 Pro-Apoptotic and Anti-Apoptotic Factors 33:22 Efferocytosis and Macrophage Clearance 38:19 Phosphatidylserine and “Eat Me” Signal 40:16 Apoptotic Bodies and Silent Clearance 44:19 DNA Laddering on Agarose Gel 45:39 Failure of Apoptosis in Cancer 46:37 Apoptosis vs Necrosis – Key Differences 49:35 Final Exam Summary of Apoptosis Dr Anusha Pro Tip: Examiners frequently ask about the Caspase cascade and the Bcl-2 family. When writing a long note, always separate the intrinsic and extrinsic pathways into clean flowcharts and emphasise that apoptosis does not cause inflammation. This distinction is what separates a top-scoring paper from an average one! Check out the full Pathology Most Wanted Series playlist on our channel :    • Pathology for BDS 2nd Year | Most Wanted S...   _______________________________________ 📚 Part of the "Most Wanted Series": This series is dedicated to the BDS 2nd Year community, covering Pathology, Microbiology, and Dental Materials in a way that makes learning feel like a breeze. We follow the latest DCI (Dental Council of India) curriculum to ensure you stay ahead of your batch. 👩‍⚕️ About Dr. Anusha Rathi: Dr. Anusha Rathi is renowned for her ability to simplify the "dry" subjects of Pathology and Microbiology. Her teaching style focuses on conceptual clarity, visual learning, and exam strategy, helping thousands of dental students secure distinctions. _______________________________________ PW MedEd BDS Instagram : https://www.instagram.com/pw_meded_bd... _______________________________________ #Pathology #Apoptosis #DrAnushaRathi #BDS2ndYear #CellDeath #Caspases #GeneralPathology #MostWantedSeries #OneShotRevision #DentistryStudents #NEETMDS #ExamPreparation #pwmededbds #bds