The Great American Drug Deal Explained

Download your free HEOR Roadmap here: https://mirkovonhein.com/roadmap Get my free weekly HEOR newsletter: https://pharmaradar.beehiiv.com/ Want to master HEOR? Enrol in my structured training: https://mirkovonhein.com/course ---------------------------------------- VIDEO SUMMARY 🎬 I discuss “The Great American Drug Deal”, a book about the U.S. pharmaceutical industry written by Peter Kolchinsky 📚💊🤝 Want to learn about the tricks “Bad Pharma” uses to make billions? Watch this 👉    • Is Big Pharma Evil?   ---------------------------------------- CONNECT WITH ME 📲 Twitter: https://x.com/vonHeinMirko LinkedIn:   / mirko-von-hein-b9885110b   Instagram:   / mirkovonhein   Facebook: https://www.facebook.com/profile.php?... ---------------------------------------- TIMECODES ⏰ 0:00 Intro & Background 1:30 Agenda / Topics in this Video 1:37 The Biotech Social Contract 3:27 Generic Drug Armamentarium 5:17 Branded Drugs as an Investment 6:38 How America Breaks the Contract 10:40 Pharmacy Benefit Managers 12:55 Contractual Genericization 15:10 Price-Jacking of Off-Patent Drugs 16:03 Lower Drug Pricing in Other Countries Outside the U.S. 19:27 Direct-to-Consumer Advertising (DTCA) 21:27 Short Exclusivity Extensions 23:55 Looking for a Different Perspective on Pharma? ---------------------------------------- SUBSCRIBE TO MY CHANNEL 🔔    / @mirkovonhein   ---------------------------------------- REFERENCES 📚 The Great American Drug Deal: A New Prescription for Innovative and Affordable Medicines (by Peter Kolchinsky): https://www.amazon.co.uk/Great-Americ... Prescription Drug Prices in the US versus other countries: https://www.rand.org/news/press/2024/... Finegold, K., Conmy, A., Chu, R. C., Bosworth, A., & Sommers, B. D. (2021). Trends in the USUSninsured population. Washington, DC: Office of the Assistant Secretary for Planning and Evaluation. Available here: https://aspe.hhs.gov/sites/default/fi... Top 10 Pharma Markets (IQVIA data): https://www.iqvia.com/-/media/iqvia/p... Life Expectancy vs. Health Expenditure: https://ourworldindata.org/financing-... Mulcahy AW, Schwam D, Lovejoy SL. International Prescription Drug Price Comparisons: Estimates Using 2022 Data. Rand Health Q. 2024 Jun 3;11(3):5. PMID: 38855386; PMCID: PMC11147645. Available here: https://pmc.ncbi.nlm.nih.gov/articles... Struggling With Errors, DOGE Deletes Billions More From List of Savings. Available here: https://www.nytimes.com/2025/03/03/us... Shrank, W. H., Rogstad, T. L., & Parekh, N. (2019). Waste in the US health care system: estimated costs and potential for savings. Jama, 322(15), 1501-1509. Available here: https://jamanetwork.com/journals/jama... ABPI Patent Protection Graphic: https://www.abpi.org.uk/international... Dieleman, J. L., Squires, E., Bui, A. L., Campbell, M., Chapin, A., Hamavid, H., ... & Murray, C. J. (2017). Factors associated with increases in US health care spending, 1996-2013. Jama, 318(17), 1668-1678. Health Insurance Coverage in the United States: 2023 Current Population Reports. Available here: https://www.census.gov/library/public... Patient Education: From medical paternalism to patient-centred care. Available here:   / patient-education-from-medical-paternalism...   Seeley, E., & Kesselheim, A. S. (2019). Pharmacy benefit managers: practices, controversies, and what lies ahead. Issue Brief (Commonw Fund), 2019, 1-11. Mattingly, T. J., Hyman, D. A., & Bai, G. (2023, November). Pharmacy benefit managers: History, business practices, economics, and policy. In JAMA Health Forum (Vol. 4, No. 11, pp. e233804-e233804). American Medical Association. Rome, B. N., Egilman, A. C., & Kesselheim, A. S. (2022). Trends in prescription drug launch prices, 2008-2021. JAMA, 327(21), 2145-2147. Woolf, S. H., Grol, R., Hutchinson, A., Eccles, M., & Grimshaw, J. (1999). Potential benefits, limitations, and harms of clinical guidelines. Bmj, 318(7182), 527-530. ---------------------------------------- HASHTAGS 🏷️ #USHealthcare #DrugPricing #PharmaEconomics