Unproven Peptides, GLP1s, and Reversing America's Obesity Rate — Dr. Krishna Vedala

Dr. Krishna Vedala is a board-certified internal medicine and obesity medicine physician based in Oklahoma City, with a Master of Public Health and an MBA. He is the host of the Connected by Health podcast and a passionate advocate for prevention, physician leadership, and making obesity medicine accessible to all patients. In this episode, you'll learn: – What peptides are and why only one is truly FDA approved – How GLP-1s reversed the US obesity rate for the first time ever – How dual and triple agonists differ — and which one best preserves muscle – What labs to monitor if your patients utilize unproven peptides – How GLP-1s are getting patients off blood pressure meds, insulin, and diabetic drugs – Where oral formulations, pediatric prevention, and new indications are headed Timestamp: [00:00] Dr. Vedala's background in internal medicine, obesity medicine, public health, and why he ended up in primary care [09:17] Peptides 101: what they are, which are FDA approved, and the difference between GLP-1s and unproven compounds like TB500, NAD+, and ipamorelin [13:18] The US obesity rate dropped from 39% to 36% — the first reversal ever — with 11% of Americans now on a GLP-1 [16:47] Compounded GLP-3 from China, patient overdoses, and what clinicians can actually say or do [22:19] Tapering off GLP-1s: why weight comes back without lifestyle change, and how to find the right maintenance dose [28:18] From semaglutide to tirzepatide to retatrutide: why the glucagon receptor changes the muscle-wasting equation [41:19] Emerging indications: autoimmune disease, alcoholism, Alzheimer's dementia, and the type 3 diabetes theory [44:03] Getting patients off blood pressure medication, insulin, and cholesterol drugs — and why that's the actual goal [53:34] Obesity medicine in 10 years: oral GLP-1s, pediatric prevention strategies, and the decline of injectable reliance [58:51] How to evaluate a compounding pharmacy: ingredient sourcing, sterility protocols, and pricing red flags Connect with Dr. Krishna Vedala: Podcast: https://connectedbyhealthpodcast.com/ Connect with Akshita: Instagram: @diveintohealthmd | Website: http://diveintohealthmd.com This episode is for educational purposes only and does not constitute medical advice. Please consult your physician before making changes to your medications or health regimen.