1615-Multi-Omic Profiling of Hepatocellular Carcinoma

The paper outlines a comprehensive genomic and transcriptomic study of hepatocellular carcinoma (HCC) aimed at refining the disease's molecular classification. By integrating multi-omics data from 529 French patients and validating findings in an external cohort of over 800 cases, researchers identified nine distinct molecular subtypes driven by specific mutations and immune profiles. Key findings include the discovery of a rare, aggressive TP53+CTNNB1ex3 subtype, where TP53 mutations typically precede β-catenin activation, leading to poor clinical outcomes. The study also characterizes rare subtypes such as HNF1A-mutated HCC, which develops in non-fibrotic livers, and evaluates the functional impact of driver genes on the p53 and WNT/β-catenin pathways. Ultimately, this research provides a clinically relevant framework for precision medicine, offering an interactive web tool to help tailor liver cancer treatments based on individual tumor biology. References: • Pan L, Hirsch T Z, Fang J, et al. Integrated genomic analyses identify oncogenic pathway interplay in hepatocarcinogenesis defining specific molecular subtypes[J]. Nature Communications, 2026. 前往小宇宙评论区与主播互动 (https://www.xiaoyuzhoufm.com/episode/...)