The Clinical Science and Mechanism of Action of CCM Therapy | Impulse Dynamics

A green screen clinical presentation produced by Perlow Productions for Impulse Dynamics, a medical device company. In this presentation, Ishu Rao explains the clinical science and mechanism of action of CCM therapy. Perlow Productions produced it in a green screen studio as part of a series of clinical presentations, with graphics and visuals added behind the presenter in post-production. Medical device projects like this typically include legal and regulatory review of the script and the final video, and we build that time into the schedule from the start. Is your company planning a clinical or medical education video? Perlow Productions works with clients nationwide. Schedule a conversation with Mike Perlow: https://calendly.com/perlowproduction... See more of our medical work: https://perlowproductions.com/service... Chapters 0:00 Introduction and the Heart Failure Landscape 1:20 Optimizer Smart Therapy Delivery and Waveform 2:45 Device Implant and Lead Positioning 3:45 Conduction Velocity: Distinguishing SVT from VT and PVC 6:15 How CCM Therapy Works 8:40 Effects on Intracellular Calcium 11:30 CCM and Myocardial Efficiency 12:05 Gene Programs Implicated in Heart Failure 14:15 CCM and Sympathetic Activity 16:10 Clinical Trial Evidence and Peak VO2 20:15 Who CCM Therapy Is For 21:25 The Cardi-o-meter: CCM or CRT 22:45 FIX-HF-5 Subgroup Analysis by Ejection Fraction 23:30 FIX-HF-5C Demographics and Results 25:15 Ischemic vs Non-Ischemic Patients 26:15 CCM vs CRT Landmark Trials and ESC Guidelines 28:05 Concomitant Devices and the EU Registry 28:20 Tricuspid Regurgitation and Permanent Leads 30:10 Protect Pace Sub-Study 34:50 CCM-REG Long-Term Registry 37:30 CCM Registry of 503 Patients 39:10 Reduced Hospitalizations 40:15 Pooled Data by Ejection Fraction 41:10 The Optimizer Smart System About Perlow Productions Perlow Productions is a corporate video production and animation company serving pharma, life sciences, technology, manufacturing and consumer brands. For two decades, we have helped marketing, sales and HR leaders turn complex subjects into compelling stories, from facility tours and product demos to animated explainers and recruiting videos. Clients include Dell Technologies, Scrub Daddy, Hikma Pharmaceuticals and The Okonite Company. Subscribe for new client videos:    / @perlowproductions   Mike@PerlowProductions.com · (856) 669-1669 · PerlowProductions.com