How GPCRs Work!?📚Complete Signaling Pathway with Diagrams and Explanation👉Gs, Gi, Gq, cAMP, IP3, DAG

Master G-Protein Coupled Receptors (GPCRs) in one comprehensive video! 🧬 In this lecture, we break down the entire GPCR signaling mechanism step-by-step—from ligand binding to downstream cellular cascades involving Gs, Gi, and Gq proteins, Adenylyl Cyclase, cAMP, PKA, Phospholipase C (PLC), IP3, DAG, and intracellular Calcium release. Whether you are preparing for USMLE, MCAT, NEET-PG, CSIR NET Life Sciences, Pharmacy (GPAT), or university physiology and biochemistry exams, this visual guide provides all the high-yield concepts and pathways you need. 📌 Timestamps: Introduction to G-Protein Coupled Receptors (GPCRs) GPCR Structure: 7-Transmembrane Domains & Heterotrimeric G-Proteins Receptor Activation Cycle: GDP to GTP Exchange The G_s Pathway: Adenylyl Cyclase, cAMP & Protein Kinase A (PKA) The G_i Pathway: Adenylyl Cyclase Inhibition & Regulation The G_q Pathway: Phospholipase C (PLC), IP_3, DAG & Ca^{2+} Release Signal Termination: GTPase Activity, Phosphodiesterases (PDEs), & \beta-Arrestin High-Yield Clinical Pharmacology & Disease Correlations Summary & Key Takeaways 💡 Key Takeaways Covered: G_s pathway: Stimulates adenylyl cyclase \rightarrow increases cAMP \rightarrow activates PKA. G_i pathway: Inhibits adenylyl cyclase \rightarrow decreases cAMP \rightarrow dampens downstream phosphorylation. G_q pathway: Activates Phospholipase C \beta (PLC$\beta$) \rightarrow cleaves \text{PIP}_2 into IP_3 and DAG \rightarrow induces Ca^{2+} efflux from the sarcoplasmic/endoplasmic reticulum and activates Protein Kinase C (PKC). Desensitization: GRKs (G-protein receptor kinases) and \beta-arrestin mediated internalization. 🔔 Subscribe for more visual medical and biology breakdowns: [Your Channel Link] 👍 Like and share if this helped make GPCR signaling simple! 💬 Drop your questions or topic requests in the comments below! #GPCR #CellSignaling #Biochemistry #Pharmacology #USMLE #MCAT Hashtags (Top 35 for Description & Socials) #GPCR #GProteinCoupledReceptor #CellSignaling #SignalTransduction #Biochemistry #Pharmacology #Physiology #MedicalSchool #USMLE #USMLEStep1 #MCAT #NEETPG #CSIRNET #GPAT #CellBiology #cAMP #IP3 #DAG #PKA #PKC #AdenylylCyclase #PhospholipaseC #MolecularBiology #BiologyLecture #MedStudent #ScienceEducation #DoctorInTraining #PreMed #Pharma #Biotech #NCLEX #Endocrinology #Neuroscience #StemCells #HighYield