2025 ELN Recommendations on the Management of CML

Professor Jane Apperley Imperial College, London (UK) The European LeukemiaNet (ELN) has issued expert consensus recommendations for managing CML since 2006, with updates in 2009, 2013, and 2020. The 2025 version, recently accepted for publication in Leukemia, reflects evolving clinical data, new therapies, and a growing emphasis on individualised care. The full publication can be accessed here: https://www.nature.com/articles/s4137... 00:40 ELN recommendations: process 04:14 Defining disease phase in CML - including new WHO criteria for defining disease phase in CML 10:58 Prognosis at diagnosis - including impact of ASXL1 mutation at diagnosis 17:43 Monitoring response to treatment 19:08 Response milestones 2025 - including 'Why personalise the milestones?' 31:32 First-line treatment - including first-line treatment with asciminib 36:20 Resistance 38:14 Treatment-free remission 39:22 Parenting - including pregnancy outcomes and planning a pregnancy in established CML 42:33- Adverse events