Reflecting on 25 Years of the Wisconsin Registry for Alzheimer’s Prevention

Twenty-five years ago, a single participant enrolled in what would become the Wisconsin Registry for Alzheimer's Prevention (WRAP), now one of the largest and longest-running studies of Alzheimer's risk in the world. To celebrate this milestone, we’re joined by Dr. Mark Sager, who co-founded WRAP, along with current multi-principal investigators Dr. Sterling Johnson and Dr. Jessica Caldwell, to discuss how the study has evolved, the discoveries that have reshaped our understanding of Alzheimer's prevention, and what the next 25 years may hold for the field. Guests: Mark Sager, MD, founder, Wisconsin Alzheimer’s Institute (WAI), WRAP, Sterling Johnson, PhD, multi-principal investigator, WRAP, associate director, Wisconsin Alzheimer’s Disease Research Center, WAI, Jessica Caldwell, multi-principal investigator, WRAP, visiting associate professor, department of neurology, University of Wisconsin-Madison Show Notes Listen to our episode with Dr. Gina Green-Harris, mentioned at 12:27, on our website: https://dementiamatters.adrc.wisc.edu... Learn more about WRAP on the WRAP website: https://wrap.wisc.edu/ Learn about Drs. Sager, Johnson and Caldwell at their profiles on the WAI website: https://wai.wisc.edu/wai-founder/, https://wai.wisc.edu/staff/johnson-st..., https://wai.wisc.edu/staff/caldwell-j... Connect with us Find transcripts and more at our website: https://www.adrc.wisc.edu/dementia-ma... Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook, Instagram and Twitter:   / wisconsinadrc  ,   / uw_dementiamatters  ,   / wisconsinadrc   Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter: https://www.adrc.wisc.edu/newsletter Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production: https://supportuw.org/giveto/dementia... Learn about Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia: https://read.macmillan.com/lp/when-me... Produced by the Wisconsin Alzheimer's Disease Research Center © 2026 Board of Regents of the University of Wisconsin System