Video 3: From Diagnosis to Management: How to Treat Tardive Dyskinesia

In this video, PA Williams explores the management of Tardive Dyskinesia (TD), discussing its pathophysiology and emphasizing the importance of appropriate treatment strategies. He advocates for the use of VMAT2 inhibitors while clarifying common misconceptions about antipsychotic medications in TD management. Series sponsored by Neurocrine Biosciences. To watch the full series, visit aapa.org/VitalRounds References and Additional Resources: American Psychiatric Association. The American Psychiatric Association Practice Guideline for the Treatment of Patients with Schizophrenia. American Psychiatric Association Publishing; 2020. https://psychiatryonline.org/doi/book... Bhidayasiri R, Jitkritsadakul O, Friedman JH, Fahn S. Updating the recommendations for treatment of tardive syndromes: A systematic review of new evidence and practical treatment algorithm. J Neurol Sci. 2018;389:67-75. doi:10.1016/j.jns.2018.02.010 Caroff SN. A new era in the diagnosis and treatment of tardive dyskinesia. CNS Spectr. 2023;28(4):401-415. doi:10.1017/S1092852922000992 New Data from Teva Shows Substantial Rates of Undertreated Tardive Dyskinesia in Long-Term Care Settings at Psych Congress Elevate 2025. Tevausa.com. Accessed August 5, 2025. https://www.tevausa.com/news-and-medi... Ruparelia P, Pandya U, Gill N, Verma O. Restless tongue: Lingual Tardive Dyskinesia - A rare case report. J Oral Biol Craniofac Res. 2022;12(1):99-101. doi:10.1016/j.jobcr.2021.10.006 Stahl SM. Neuronal traffic signals in tardive dyskinesia: not enough “stop” in the motor striatum. CNS Spectr. 2017;22(6):427-434. doi:10.1017/S109285291700061X Takeuchi H, Mori Y, Tsutsumi Y. Pathophysiology, prognosis and treatment of tardive dyskinesia. Ther Adv Psychopharmacol. 2022;12:20451253221117313. doi:10.1177/20451253221117313 Vanegas-Arroyave N, Caroff SN, Citrome L, et al. An evidence-based update on anticholinergic use for drug-induced movement disorders. CNS Drugs. 2024;38(4):239-254. doi:10.1007/s40263-024-01078-z Ward KM, Citrome L. Antipsychotic-related movement disorders: Drug-induced parkinsonism vs. Tardive dyskinesia—key differences in pathophysiology and clinical management. Neurol Ther. 2018;7(2):233. doi:10.1007/s40120-018-0105-0