Aspirin after hip or knee replacement and risk of VTE

When is it truly safe to use aspirin alone over full-strength anticoagulation after major joint surgery? In this episode of McMaster Perspective Dr James Douketis joins Dr Roman Jaeschke to break down the latest findings from the EPCAT III trial and what they mean for daily inpatient care. They discuss why aspirin alone is becoming a safe, practical option for low-risk patients undergoing elective hip or knee arthroplasty while stressing why high-risk cases and hip fractures still require full-strength anticoagulation. 📝 Complete transcript and references: https://mcmastertextbook.one/en/knowl... 00:00 Introduction 00:47 EPCAT III study on thromboprophylaxis after hip or knee arthroplasty 02:46 Evolution in arthroplasty 05:17 Risk stratification and individualized thromboprophylaxis 08:29 Restarting anticoagulants after neuraxial anesthesia 10:30 Thromboprophylaxis after hip fracture surgery 14:08 Professional practice variations between specialties 15:32 Upcoming PEPPER trial [Pulmonary Embolism Prevention After HiP and KneE Replacement] 17:56 Key takeaways The McMaster Perspective interview series is a collection of in-depth conversations that brings together the world’s leading medical experts and McMaster University’s renowned evidence-based medicine approach. YouTube playlist:    • McMaster Perspective   📌 McMaster Perspective is part of the McMaster Textbook Network. See more at https://www.mcmastertextbook.one Disclaimer: The information discussed in this interview is intended for educational and informational purposes only and should not be considered medical advice. Viewers should consult a qualified health care professional for diagnosis and treatment of any medical condition. #McMasterPerspective #MedEd #thrombosis