The Binding of Isaac | Daily Run 15th Sept 2026 (Rank: 108)

Goal: Keeper vs. ??? [Normal Difficulty] Spiciest Stuff: Squeezy, Restock, Lil Steven, Schoolbag, Sack Head, Spindown Dice, Lost Contact, Mr. Dolly, Act of Contrition, Humbling Bundle, Car Battery, Meat Cleaver, Knockout Drops, Pentagram, Odd Mushroom (small), Rotten Baby, Euthanasia, Haemolacria Transformations: Spun Are we actually gonna get every character before a (non-curated run) dupe? Keeper is up which leaves us with only three characters left to show! We've got a really nice run on our hands here. Brimstone was available from the first Devil Room (I was three pennies short, maybe for the best, it's slooow with Keeper). We got a notably good Tear Rate here which left us being very formidable. The DMG took over at the end with Haemolacria, felt even more powerful. Schoolbag got a bit of use here too – started with Spindown Dice and then swapped for Meat Cleaver (more enemies=more points!) Too slow for Boss Rush (skill issue pretty much...). Desperately spent every penny in the shop hoping for Mama Mega, but nope. Made Hush easier to reach at least. Night Light and Lost Contact took care of the bullet hell (erratically). Had one doubled use of the Wooden Nickel as back up but was fortunately enough not to need it. Apart from the above, defensively we also get Divine Intervention – an item that I almost always immediately forget I've got unless it's all I've got – not even one use here... We've also got a back up life from the Ankh! I had a blast here, it's a shame missing Boss Rush of course, but I'm having an up-and-down month it seems 🤷‍♂️ Best of luck! Fun rating: ⭐⭐⭐⭐ ☕ | https://www.ko-fi.com/thebiroofisaac 👈 Tip me a coffee? ✅ |    / @the_biro_of_isaac   👈 Subscribe? 📷 |   / the_biro_of_isaac   👈 TBoI Instagram art project 🖊 #thebindingofisaac #bindingofisaac #tboi