Keynote 689: Multidisciplinary Care for Immunotherapy in Head & Neck Cancer | ENT Ep. 247

When treating head and neck cancer, how can you tell the difference between true disease progression and pseudoprogression? In this episode of the BackTable Podcast, we discuss the practical implementation of the KEYNOTE-689 trial published in the New England Journal of Medicine, which demonstrated the benefit of adding neoadjuvant and adjuvant immunotherapy to standard head and neck cancer care. Our tumor board panel includes Dr. Mihir Patel, a head and neck surgeon from UNC Chapel Hill, Dr. Siddharth Sheth, a head and neck medical oncologist from UNC, Dr. Jennifer Johnson, a professor of medical oncology and otolaryngology at Sidney Kimmel Comprehensive Cancer Center, and Dr. Adam Luginbuhl, a head and neck surgical oncologist at Thomas Jefferson University. --- SYNPOSIS The doctors address the trial's practical implications, patient selection, case management, dealing with tumor progression, and the integration of multidisciplinary care. They also emphasize the importance of communication, real-world application of trial protocols, and the potential benefits and challenges of such therapies. --- TIMESTAMPS 00:00 - Introduction 03:18 - Discussing the New Indication for Immunotherapy 11:42 - Challenges and Practical Implementation 22:48 - Managing Tumor Progression: A Case Study 28:07 - Exploring Treatment Options: Surgery vs. Chemotherapy 36:46 - Operational Challenges and Future Directions 43:58 - Concluding Thoughts and Future Directions --- RESOURCES Keynote 689 https://www.nejm.org/doi/full/10.1056... --- The BackTable ENT Podcast is a resource for otolaryngologists to learn tips, techniques, and practical advice on all things ear, nose, and throat. Tune in to the BackTable ENT Podcast every week for candid conversations about rhinology, laryngology, otology, and head and neck surgery. Get notified when new episodes drop! Subscribe to the BackTable ENT Podcast on your go-to podcast platform, and follow us on your social media platform of choice for regular otolaryngology updates. ► https://www.backtable.com/shows/ent/s... #ENT247 #headandneckcancer #oncology #ent