Extracellular Y-RNA - Esther Nolte-'t Hoen & Tom Driedonks

In this lecture from Week 2 of the Extracellular RNA Online Course, Esther Nolte-'t Hoen from Utrecht University and Tom Driedonks from University Medical Center Utrecht give a focused lecture on what is known about extracellular Y-RNA. Chapter Markers 00:12 Lecture Contents 00:37 Discovery of Extracellular Y-RNA 01:14 Discovery of Extracellular Y-RNA in EVs 02:07 Main Questions 03:07 Y-RNA in Biofluids 03:29 Y-RNA in Cells 04:01 Y-RNA Sequencing Studies 04:45 Cell-type-specific Differences 05:48 Fragments vs Full-length 06:28 Methods Matter! 06:58 RNA-seq vs Northern Blot 07:59 Marker 08:34 Y-RNAs as biomarkers 09:37 Function of Y-RNA in Target Cells 10:25 Conclusions