Update on the BRAINmodel project with Nael Nadif Kasri

BRAINMODEL is a Dutch consortium whose main objective is to use iPSC-based analyses to detect abnormal cellular functions in material from patients with brain disorders (including Kleefstra syndrome) and to link these to clinical outcome measures, such as EEG biomarkers and patient-relevant symptom scales. The researchers will test whether abnormal cellular properties, which cause an imbalance between the positive and negative signals that nerve cells send to one another, can be remedied with existing medication in the iPSC-based analyses. I will present an overview of the current state of the project.