Why Is There Still No Cure for the Common Cold?

We wiped out smallpox and built COVID vaccines in under a year. So why can't we cure a runny nose? 0:00 Intro 0:19 The Common Cold Unit 0:55 The enemy 1:36 The break-in 2:29 Friendly fire 3:15 The counterattack 3:56 160 keys 4:33 Why there is no cure 5:51 Myths 6:37 What actually helps 7:12 A strange ally 7:45 Outro Sources: • Common Cold Unit, Salisbury (1946–1989): Wikipedia "Common Cold Unit"; Salisbury Healthcare History • Foxman et al. (2015), PNAS: rhinovirus copies better at nose temperature because the interferon response is weaker • Bochkov et al. (2015), PNAS: rhinovirus C and its receptor CDHR3 • Lee et al. (2016), Nature Communications: a 50-valent rhinovirus vaccine in rhesus macaques • Diep et al. (2019), Nature Microbiology: SETD3 is needed by enteroviruses, including rhinoviruses • FDA Antiviral Drugs Advisory Committee, 19 March 2002: pleconaril • Hemilä & Chalker (2013), Cochrane review: vitamin C and the common cold • Bleier et al. (2022), Journal of Allergy and Clinical Immunology: cold air and the nose's extracellular vesicles • Prather et al. (2015), Sleep: short sleep and susceptibility to the common cold • Cohen, Tyrrell & Smith (1991), New England Journal of Medicine: psychological stress and the common cold • Wu et al. (2020), The Lancet Microbe: interference between rhinovirus and influenza • Dee et al. (2021), Journal of Infectious Diseases: rhinovirus blocks SARS-CoV-2 in airway tissue • CDC: "Common Cold" and "Rhinoviruses" Made by me - Time spent: 22 hours Narration: AI voice by ElevenLabs (elevenlabs.io). Animation: made in code with help from AI tools, checked by me. Music: "Clean Living" and "Jay Walking" by Everet Almond, "That's the One" by Ryan McCaffrey / Go By Ocean (YouTube Audio Library) Found a mistake? Comment and I'll pin the correction. #science #biology #commoncold