CFB Week 6 Preview: Indiana vs Nebraska, LSU vs Kentucky, USC vs Penn State

Joe DeLeone and Blake Ruffino share their College Football Week 6 preview, breaking down Kentucky vs LSU, Indiana vs Nebraska and USC vs Penn State. Their 2026 college football preview examines three conference matchups with SEC football, Big Ten football and College Football Playoff (CFP) stakes as teams approach the heart of the season. LSU football, Indiana football and USC football all face road environments that could test their conference championship ambitions. Joe and Blake examine the keys to victory, quarterback play, defensive matchups and potential upset scenarios that make these games worth watching. Kentucky vs LSU: Kentucky football enters 4-1 after an overtime comeback against South Carolina, giving Will Stein's Wildcats momentum before hosting Lane Kiffin's LSU Tigers. Can Kentucky sustain drives and finish scoring opportunities, or will LSU control the matchup and strengthen its position in the SEC race? Indiana vs Nebraska: Indiana football and Nebraska football both enter 5-0, setting up a showdown at Memorial Stadium in Lincoln. Can Curt Cignetti's Indiana Hoosiers keep rolling, or will the Nebraska Cornhuskers turn their unbeaten start into a statement against the defending national champions? USC vs Penn State: Lincoln Riley's USC Trojans head to Beaver Stadium for Penn State's White Out game. Joe and Blake preview the challenges facing USC football and whether Penn State football can use its home atmosphere to deliver an important Big Ten win. This video covers College Football Week 6 matchups, LSU vs Kentucky analysis, Indiana vs Nebraska preview, USC vs Penn State preview, SEC contenders, Big Ten contenders and the evolving CFP picture. Share your winners in the comments and subscribe for more college football previews, rankings and reactions. #CollegeFootball #CFB #CollegeFootballWeek6 #LSUFootball #KentuckyFootball #IndianaFootball #NebraskaFootball #USCFootball #PennStateFootball #SECFootball #BigTenFootball #collegefootballplayoffs Sign up for a Kalshi account and use promo code RJS: http://kalshi.com/r/RJS #KalshiPartner (0:00) Introduction (8:15) Indiana Nebraska (32:20) LSU Kentucky (48:50) Penn State USC