105P- What is X-Linked Agammaglobulinemia, XLA, or Bruton Disease?

Visit my website for a full list of videos. Enjoy. https://drkevinmangum.com/youtube-pat... X-Linked agammaglobulinemia (XLA), or Bruton disease, is one of the more common forms of primary immune deficiency. It is characterized by the failure of pre-B cells to differentiate into B cells. XLA patients do not generate mature B cells. A mutation occurs at the Bruton's tyrosine kinase (Btk) gene that leads to a severe block in B cell development (at the pre-B to immature B cell stage) and a reduced Immunoglobulin (antibody) production in the serum.