Mutações | Curso de genética | Medicina passo a passo

Hoje analisamos as mutações , desde as mutações de poucos nucleotideos , que interferem com o quadro de leitura da informação genética , até a duplicação ou deleção de varios genes ao mesmo tempo. Tambem foi estudado varios aspectos de uma mutação no nosso genoma. ------------------------------------------------------------------------------------------------------------------------ Material Usado: 1)Título: A (corrected) chart showing the relationship between codons and amino acids. https://commons.wikimedia.org/wiki/Fi... Autor: Edited by Seth Miller User:Arapacana, Original file designed and produced by: Kosi Gramatikoff User:Kosigrim, courtesy of Abgent, also available in print (commercial offset one-page: original version of the image) by Abgent 2)Título: A cartoon illustrating the two steps of canonical RNA processing, from pre-mRNA to spliced RNA and the intron lariat https://commons.wikimedia.org/wiki/Fi... Autor: BCSteve 3)Título: The structure of a eukaryotic protein-coding gene. Regulatory sequence controls when and where expression occurs for the protein coding region (red). Promoter and enhancer regions (yellow) regulate the transcription of the gene into a pre-mRNA which is modified to add a 5' cap and poly-A tail (grey) and remove introns. The mRNA 5' and 3' untranslated regions (blue) regulate translation into the final protein product. https://commons.wikimedia.org/wiki/Fi... Autor: Thomas Shafee 4)Título: This schematic shows how the sequence of an RNA consists of triplets of nucleic acids that translate into amino acids. https://en.wikipedia.org/wiki/File:RN... Autor: Thomas Splettstoesser (www.scistyle.com) 5)Título: This image was created by the NHS National Genetics and Genomics Education Centre. For further information and resources please visit our website www.geneticseducation.nhs.uk https://en.wikipedia.org/wiki/File:Fr... Autor: Genomics Education Programme 6) Título: All nucleotide exchangeabilities in the DNA: 4 transitions and 8 transversions. https://commons.wikimedia.org/wiki/Fi... Autor: Manudouz. Note: this work is an adapted version of Transitions-transversions-v4.svg created by Petulda. It has been transformed to show all possible transitions and transversions. It is distributed under the same license (Creative Commons Attribution-Share Alike 4.0 International license). 7) Título: One of the nucleotides (adenine) is replaced by another (cytosine) in the DNA sequence. This results in an incorrect amino acid being incorporated into the protein sequence. https://en.wikipedia.org/wiki/File:Mi... Autor:U.S. National Library of Medicine 8) Título: Canonical Nonsense-mediated decay (NMD) pathway https://commons.wikimedia.org/wiki/Fi... Autor: Mariuswalter