Excitation-Contraction Coupling | Skeletal Muscle Physiology

Learn how an action potential from a motor neuron triggers contraction in skeletal muscle 2 basic phases 1) events at the neuromuscular junction leading to excitation 2) excitation leading to the release of calcium and initiation of the cross bridge cycle (contraction) due to the release of calcium Terminology/concepts covered in this video: action potential propagation, anatomy of the neuromuscular junction, actin and myosin, sarcomeres, sarcolemma, myofibrils, t tubules, the sarcoplasmic reticulum, troponin, tropomyosin, voltage gated ion channels vs ligand gated channels vs mechanically gated channels, end plate potentials vs action potentials For more videos on muscle physiology and microanatomy:    • Muscle Physiology and Microanatomy   And as promised, a diagram of the set up of the voltage sensitive proteins/mechanically gated ion channels on the t tubules/sarcoplasmic reticulum: https://slideplayer.com/slide/1370829... 00:00 intro 1:45 Review of action potentials 4:15 Review of anatomy of the neuromuscular junction 5:40 Events at the neuromuscular junction leading to excitation 7:10 Action potentials vs end plate potentials 8:50 Events in muscle cell leading to the release of calcium 12:00 Initiation of the cross bridge cycle due to the release of calcium 14:40 How does the process stop? 15:56 All steps in the process reviewed on one slide