Cell Cytoskeleton | Microfilament | Actin Protein Assembly | TNS CONCEPTS | CSIR NET LIFE SCIENCE
The Nilesh Soni
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Cell Cytoskeleton | Microfilament | Actin Protein Assembly | TNS CONCEPTS | CSIR NET LIFE SCIENCE
18 053 просмотра · 1 год назад
The Nilesh Soni
50 тыс. подписчиков
18 053 просмотра · 1 год назад
Cytoskeleton is an important topic for almost all the exams.
In this Lecture we are going to focus on following concepts:
Microfilaments : They are polymers of the protein actin that are organized into functional bundles and networks by actin- binding proteins.
Microfilaments are especially important in the organization of the plasma membrane, giving shape to surface structures such as microvilli. Microfilaments can function on their own or serve as tracks for ATP-powered myosin motor proteins, which provide a contractile function (as in muscle) or ferry cargo along microfilaments.
Microtubules are long tubes formed by the protein tubulin and organized by microtubule-associated proteins. They often extend throughout the cell, providing an organizational framework for associated organelles and structural support to cilia and flagella. They also make up the structure of the mitotic spindle, the machine for separating duplicated chromosomes at mitosis. Motor proteins called kinesins and dyneins transport cargo along microtubules; like myosins, they are powered by ATP hydrolysis.
Intermediate filaments are tissue-specific filamentous structures that serve a number of different functions, includ- ing lending structural support to the nuclear membrane, providing structural integrity to cells in tissues, and serving structural and barrier functions in skin, hair, and nails. Unlike microfilaments and microtubules, intermediate filaments are not used as tracks by motor proteins.
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