Diagnosis of Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a genetic disorder with a guarded prognosis which occurs in about 1:500 individuals. Echocardiography is the sheet anchor of diagnosis of HCM and other modalities are complementary. It is an autosomal dominant disorder with variable penetrance with either a defect in sarcomeric protein genes which encode for myosin heavy chain, actin or tropomyosin or due to abnormal myocardial Ca++ kinetics which increase intracellular Ca++, causing hypertrophy and cellular disarray. https://johnsonfrancis.org/profession...