GI Clinical Updates: Intestinal Failure, EoE & the IBD Microbiome

Explore practical and emerging updates in gastroenterology in this presentation from the Division of Gastroenterology at Mayo Clinic. This session features three focused presentations covering intestinal failure, eosinophilic esophagitis (EoE), and the evolving role of the gut microbiome in inflammatory bowel disease (IBD). Dr. Lindsay Russell begins with practical updates in intestinal failure, including short bowel syndrome, nutritional and fluid management, medical therapies, and advances in treatment. Dr. Kathy Peterson reviews eosinophilic esophagitis, including evolving concepts in diagnosis, the role of eosinophils, treatment approaches, and emerging research. Dr. John Gubatan concludes with a state-of-the-art discussion of inflammatory bowel disease and the gut microbiome, including dysbiosis, probiotics and prebiotics, fecal microbiota transplantation, and microbiome-directed therapies. The presentations are followed by a Q&A addressing practical clinical questions from the audience. This webinar is part of a quarterly educational series featuring faculty from Mayo Clinic’s Divisions of Gastroenterology across Florida, Rochester, and Arizona, highlighting emerging research, clinical innovations, and evolving best practices in gastrointestinal care. Topics include: • Intestinal failure and short bowel syndrome • Nutrition and hydration management • Eosinophilic esophagitis (EoE) • EoE diagnosis and treatment • Inflammatory bowel disease (IBD) • Gut microbiome and dysbiosis • Probiotics, prebiotics, and fecal microbiota transplantation • Emerging microbiome-directed therapies • Clinical Q&A This presentation is intended for educational purposes. 0:00 Welcome and Gastroenterology Webinar Overview 1:35 Understanding Intestinal Failure and Clinical Impact 2:40 Classifying Intestinal Failure and Short Bowel 6:30 Nutrition and Hydration Treatment Strategies 9:33 Parenteral Nutrition Benefits and Complications 11:51 Medications and Emerging Hormonal Therapies 14:02 Surgery and Intestinal Transplantation Options 17:53 Updates in Eosinophilic Esophagitis 18:55 EoE Genetics, Inflammation and Disease Mechanisms 21:16 Diagnosing EoE Beyond Symptoms and Eosinophils 24:40 Current EoE Treatment Recommendations 27:15 Dupilumab and Food Reintroduction Strategies 30:58 Emerging EoE Therapies and Esophageal Dilation 34:51 IBD and the Gut Microbiome 38:23 Probiotics, Prebiotics and Microbiome Transplantation 43:34 Next-Generation Microbiome Therapies 44:49 Diet Strategies for Inflammatory Bowel Disease 47:50 Low FODMAP, Fasting and Nutrition Research 52:49 Practical Microbiome Counseling for IBD 55:35 Expert Questions and Clinical Discussion