Episode 7: GLP-1s and Idiopathic Intracranial Hypertension

In Episode 7 of From Paper to Clinic, host Hamza Shah, OD, MS, FAAO, is joined by Leonard Messner, OD, vice president and professor of optometry at the Illinois College of Optometry, to discuss idiopathic intracranial hypertension—and what a landmark exenatide trial reveals about how GLP-1 receptor agonists may change how we manage it. Messner walks through the biology behind GLP-1's effect on intracranial pressure, the clinical significance of a 5–6 cm CSF pressure drop that appeared within 2.5 hours and persisted independent of weight loss, and what the emerging evidence means for ODs co-managing IIH patients today. The conversation also covers his full diagnostic framework: case history, OCT morphology, Bruch's membrane displacement, ganglion cell complex monitoring, and when—and why—to review the MRI yourself. The paper inspiring this discussion: "The Effect of GLP-1RA Exenatide on Idiopathic Intracranial Hypertension: A Randomized Clinical Trial" by Mitchell JL et al., published in Brain: https://doi.org/10.1093/brain/awad003 🎙 Subscribe to the show: ▶ YouTube:    / @frompapertoclinic   🍎 Apple Podcasts: https://podcasts.apple.com/us/podcast... 🟢 Spotify: https://open.spotify.com/show/4FBqlMn...