1. Pathogens, Commensals and the First Line of Defence

Trillions of microorganisms live on your skin, in your mouth and in your gut. Almost none of them are trying to hurt you. So what makes the rare one dangerous? Episode 1 of our immunology series looks at what actually separates a commensal from a pathogen, and at the four layers of defence standing between you and infection — long before a single lymphocyte is involved. Covered in this episode: 00:00 The microbes living on you right now 00:00 Four categories of pathogen, and how each damages tissue 00:00 The microbiome, and why damage is the dividing line 00:00 Avoidance, resistance and tolerance 00:00 Why immunological tolerance means something completely different 00:00 The four layers: barriers, complement, innate cells, adaptive immunity 00:00 Minutes versus days: the speed problem More from Rheumatology Digest: Website: https://rheumatologydigest.org WhatsApp channel: https://whatsapp.com/channel/0029Vb6P... #immunology #innateimmunity #medicalstudent #janeway #usmle #neetpg