Takayasu arteritis (aortic arch syndrome) - Pathology of blood vessels / Vasculitis

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash Takayasu arteritis (aortic arch syndrome) ------------------------------------------------------------------- Definition: granulomatous inflammation of the aorta and its major branches, resulting in stenosis of involved blood vessels and subsequent vascular symptoms Epidemiology ---------------------- Peak incidence: 15–45 years of age Asian heritage male to female ratio (3:1) Clinical features -------------------------- Fever, malaise, arthralgia Vascular symptoms Decreased bilateral brachial and radial pulses → “pulseless disease” Syncope, angina pectoris Impaired vision Movement-induced muscular pain in one or more limbs Raynaud phenomenon Bilateral carotid bruits Hypertension Skin manifestations Erythema nodosum Urticaria Diagnostics ------------------- Laboratory findings: ↑ ESR Angiography (gold standard): detects vascular stenosis Biopsy of affected vessel: granulomatous thickening of aortic arch; plasma cells and lymphocytes in media and adventitia; vascular fibrosis Treatment ----------------- Corticosteroids; if necessary, MTX or cyclophosphamide may be administered Surgical intervention (e.g., bypass) may be required if critical stenosis of the aortic arch or its branches occurs. Antihypertensive treatment #Takayasuarteritis #vascularpathology #usmlevideos #takayasuarteritispathology #pathologyvideos #patholectures #animatedmedicalvideos #usmlevideos #usmlestep1videos #drgbhanuprakash