Ketamine for Unipolar Depression

This clip, from NEI's Stahl's Essential Videos, covers how ketamine could be a potential treatment option for depression. Access the full video collection here https://nei.global/epvideo Ketamine is an approved anesthetic but used off-label for treatment-resistant depression. So, how does ketamine induce its rapid antidepressant response and rapid reversal of synaptic atrophy in depression? This is thought to occur because ketamine causes an immediate burst of downstream glutamate release after blocking NMDA receptors. Most interesting perhaps is the possibility that ketamine causes immediate improvement in neuronal plasticity as its downstream mechanism of immediately improving depression. 🧠💡 Struggling to grasp complex psychopharmacologic concepts? Unlock the Power of Visual Learning with NEI's Stahl's Essential Videos! These videos are an NEI Membership feature designed to help you master the fundamentals of psychopharmacology! Learn more at https://nei.global/epvideos Start your learning journey by creating a free NEI Guest account here https://nei.global/createaccount Follow us on Facebook: https://nei.global/facebook Follow us on LinkedIn: https://nei.global/linkedin Follow us on X: https://nei.global/twitter Follow us on Instagram: https://nei.global/instagram 🎙 Listen to NEI Podcast: https://nei.global/podcast Copyright © Neuroscience Education Institute. All rights reserved.