Pharmacodynamics (part 2); types of receptors

time codes 0:00 Ligand gated ion channel 4:30 Enzyme-linked receptors 6:28 G protein coupled receptor 15:04 Intracellular receptor this amazing video describes types of receptors including: ligand gated ion channels; that are coupled directly to an ion channel. Activation opens the channel, making a cell membrane permeable to specific ions. These channels are known as ‘ligand-gated’ because it is receptor binding that operates them. examples, Nicotinic acetylcholine receptors; gamma-Aminobutyric acid (GABA) receptors. G-Protein coupled receptors that are coupled to intracellular effector mechanisms via a family of closely related 'G‐proteins' that participate in signal transduction by coupling receptor binding to intracellular enzyme activation or the opening of an ion channel. Secondary messenger systems include the enzymes, adenylyl cyclase and guanylyl cyclase, which generate cyclic AMP and cyclic GMP, respectively. action of this receptor on phospholipase C, PLC, is mentioned. examples, Muscarinic acetylcholine receptors; beta-Adrenoceptors; Dopamine receptors. Enzyme-linked receptors that are linked directly to an intracellular protein kinase that triggers a cascade of phosphorylation reactions. Insulin receptors is an example Intracellular receptors that are located intracellular and also known as 'nuclear receptors’. Binding of a ligand promotes or inhibits synthesis of new proteins, which may take hours or days to promote a biological effect. examples include: Steroid hormone receptors; Thyroid hormone receptors; Vitamin D receptors.