Vladislav Andreev — Autoimmune Illness, Remission & How Inflammation Shapes Mental Health

About Vladislav Vladislav Andreev is an executive performance coach for founders and senior executives, and founder of O!Sapiens. Nineteen years ago he was diagnosed with ankylosing spondylitis, a rare autoimmune disease, and told he would be on immunosuppressants for life. After 14 years on medication, he went into remission through behavioral intervention alone, without a medical degree and without anyone telling him it would work. In 2025 he published a paper arguing that low-grade systemic inflammation is a primary and largely overlooked driver of mental health conditions. He now works with high performers to implement the Sapiens OS framework: a 10-pillar operating system for the body, rooted in evolutionary biology and built entirely around behavior. What You’ll Learn in This Episode Inflammation theory: Why Vlad believes most mental health issues are not a chemical imbalance in the brain but an inflammatory response in the body. Sleep lie: Why almost every high performer who says they sleep fine is quietly running on a deficit, and what the science actually says about what the body demands. Sapiens OS: The 10-pillar framework Vlad built to heal himself, and why he calls it the manual we never got at birth. Curiosity deficit: Why the loss of curiosity in adult life is one of the most underestimated drivers of premature decline, and what restoring it actually changes. Safety gap: The one pillar Vlad almost left out of his framework, and why it may need to come before everything else. Get more details about our guest & key takeaways here: https://peakspan-podcast.com/guest_vl... Find us here: LinkedIn:  / about   Instagram:  / peakspan   YouTube:   / @peakspan_podcast   Website & past guests: peakspan-podcast.com A follow, a share, or a review goes a long way. Thank you for being part of the Peakspan community. Music The music for this episode was created with the assistance of AI usinghttps://makebestmusic.com. Medical disclaimer The information in this episode is for educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making decisions about your health.