A new Concept of Central Dogma, an introduction to Molecular Systems Biology

Classical concept of Central dogma and new one according to Molecular Systems Biology. Video Chapters & Time Table 00:00 – Introduction & Course Overview (Molecular Systems Biology) 01:30 – What is Molecular Systems Biology? 02:05 – Molecular Biology vs. Systems Biology: Fundamental Differences 03:20 – Biological Systems Components & Dynamics 05:46 – Core Questions in Molecular Biology vs. Systems Biology 08:37 – Reductionism vs. Holism 10:58 – Historical Background & Key Milestones 14:08 – The Classical Central Dogma of Molecular Biology 15:07 – Why the Classical Central Dogma is Incomplete in Systems Biology 17:06 – Non-linear Information Flow & Regulatory Networks 18:50 – Multi-level Regulation of Gene Expression (Epigenetics, Transcription & RNA Processing) 22:36 – Cell Differentiation & Tissue-Specific Gene Expression 24:43 – Non-Coding RNAs and Their Regulatory Roles 26:51 – Active Roles of Proteins Beyond Final Products 28:18 – Feedback Loops (Positive & Negative Regulation) 30:56 – Signaling Pathways & Environmental Response 32:25 – Integration of Metabolism and Gene Regulation (SAM, Acetyl-CoA, Glutathione) 36:42 – Dynamic Behavior of Biological Systems Over Time 38:41 – The Modern Central Dogma Network & Emergent Phenotypes 41:48 – Case Study: Lac Operon Regulation in E. coli 45:31 – Conclusion & Summary