NEJM This Week — October 15, 2026

This week, we feature new research on gene editing for hereditary angioedema, a chemotherapy-free approach to acute lymphoblastic leukemia, and treatments for ulcerative colitis and HIV. We review adult ADHD and follow a challenging case involving a spinal mass. We report on lung cancer screening, and Perspectives explore care interventions for older adults, access to fertility care, and the evolving role of AI in medicine.