Towards Understanding HLA-DQ Immunogenicity

March 22nd, 2023 "Towards Understanding HLA-DQ Immunogenicity" Presenter: Dr. Anat Roitberg-Tambur DMD PhD Director, Transplant Immunology Lag Comprehensive Transplant Centre Northwestern University Chapters: 0:00 Introduction 2:32 Opening & DQ Refresher 4:17 DQ & Virtual Crossmatching 9:25 Epitope Analysis of HLA-DQ 14:29 Improving Organ Allocation with DQ Information 22:07 DQ mismatch analysis - how & where to use it 29:29 DQ Immunogenicity - deciphering 49:35 Working Hypothesis 50:30 Q&A Learning Objectives: Understand the need to address HLA-DQAs heterodimers (combining alpha/ beta chains into one antigenic entity) Review different Molecular Mismatch Load (MML) analysis methods Explore alternative approaches to decipher immunogenicity