The Map Makers by Frederik Pohl - X Minus One, (Deep-Space SF Audio Drama)

A micro-meteorite has penetrated three of the bulkheads of the Terra II, severely injuring a crew-member and destroying the ship's navigation system. Lost in deep hyperspace, knowing they could be millions of light-years from anywhere known in the Universe, the crew must now do anything within their power to survive. Aired 26th September, 1956, on X Minus One - the science fiction radio series broadcast from 1955 to 1958 on NBC Radio