Nova EPIDEMIA de EBOLA | Por que é tão PREOCUPANTE?

Uma nova epidemia de Ebola está ocorrendo na República Democrática do Congo. Hoje vamos detalhar a Ciência por trás da letalidade desse vírus. Se você gostou do vídeo, por favor deixe sua avaliação e comentário. E se ainda não é inscrito, se inscreva! :) Contato: contato@yoshiciencia.com.br Refências Utilizadas para o vídeo: 📄 Geisbert TW, Young HA, Jahrling PB, Davis KJ, Kagan E, Hensley LE. 2003. Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event. J Infect Dis 188:1618–1629. https://doi.org/10.1086/379724 📄 Jones SM, Feldmann H, Ströher U, Geisbert JB, Fernando L, Grolla A, Klenk H-D, Sullivan NJ, Volchkov VE, Fritz EA, Daddario KM, Hensley LE, Jahrling PB, Geisbert TW. 2005. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Nat Med 11:786–790. https://doi.org/10.1038/nm1258 📄 Wahl-Jensen VM, Afanasieva TA, Seebach J, Ströher U, Feldmann H, Schnittler H-J. 2005. Effects of Ebola virus glycoproteins on endothelial cell activation and barrier function. J Virol 79:10442–10450. https://doi.org/10.1128/JVI.79.16.104... 📄 Olejnik J, Alonso J, Schmidt KM, Yan Z, Wang W, Marzi A, Ebihara H, Yang J, Patterson JL, Ryabchikova E, Mühlberger E. 2013. Ebola virus does not block apoptotic signaling pathways. J Virol 87(10). https://doi.org/10.1128/JVI.01461-12 📄 Chertow DS, Kleine C, Edwards JK, Scaini R, Giuliani R, Sprecher A. 2014. Ebola virus disease in West Africa—clinical manifestations and management. N Engl J Med 371(22). https://doi.org/10.1056/NEJMp1413084 📄 Schieffelin JS, Shaffer JG, Goba A, Gbakie M, Gire SK, Colubri A, Sealfon RSG, Kanneh L, Moigboi A, Momoh M, et al. 2014. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med 371. https://doi.org/10.1056/NEJMoa1411680 📄 Falasca L, Agrati C, Petrosillo N, Di Caro A, Capobianchi MR, Ippolito G, Piacentini M. 2015. Molecular mechanisms of Ebola virus pathogenesis: focus on cell death. Cell Death Differ 22:1250–1259. https://doi.org/10.1038/cdd.2015.67 📄 Marí Saéz A, Weiss S, Nowak K, Lapeyre V, Zimmermann F, Düx A, Kühl HS, Kaba M, Regnaut S, Merkel K, Sachse A, Thiesen U, Villányi L, Boesch C, Dabrowski PW, Radonić A, Nitsche A, Leendertz SAJ, Petterson S, Becker S, Krähling V, Couacy-Hymann E, Akoua-Koffi C, Weber N, Schaade L, Fahr J, Borchert M, Gogarten JF, Calvignac-Spencer S, Leendertz FH. 2015. Investigating the zoonotic origin of the West African Ebola epidemic. EMBO Mol Med 7:17–23. https://doi.org/10.15252/emmm.201404792 📄 Varkey JB, Shantha JG, Crozier I, Kraft CS, Lyon GM, Mehta AK, Kumar G, Smith JR, Kainulainen MH, Whitmer S, Ströher U, Uyeki TM, Ribner BS, Yeh S. 2015. Persistence of Ebola virus in ocular fluid during convalescence. N Engl J Med 372:2423–2427. https://doi.org/10.1056/NEJMoa1500306 📄 Lau MSY, Dalziel BD, Funk S, McClelland A, Tiffany A, Riley S, Metcalf CJE, Grenfell BT. 2017. Spatial and temporal dynamics of superspreading events in the 2014–2015 West Africa Ebola epidemic. Proc Natl Acad Sci U S A 114:2337–2342. https://doi.org/10.1073/pnas.1614595114 📄 Plummer FA, Jones SM. 2017. The story of Canada’s Ebola vaccine. CMAJ 189:E1326–E1327. https://doi.org/10.1503/cmaj.170704 📄 Garry RF. 2021. Ebola virus can lie low in human survivors. Nature 597:478–479. https://doi.org/10.1038/d41586-021-02... 📄 Biedenkopf N, Bukreyev A, Chandran K, Di Paola N, Formenty PBH, Griffiths A, Hume AJ, Mühlberger E, Netesov SV, Palacios G, Pawęska JT, Smither S, Takada A, Wahl V, Kuhn JH. 2023. Renaming of genera Ebolavirus and Marburgvirus to Orthoebolavirus and Orthomarburgvirus, respectively, and introduction of binomial species names within family Filoviridae. Arch Virol 168:220. https://doi.org/10.1007/s00705-023-05.... 📄 Munyeku-Bazitama Y, Edidi-Atani F, Takada A. 2024. Non-Ebola filoviruses: potential threats to global health security. Viruses 16:1179. https://doi.org/10.3390/v16081179. 📄 Riesle-Sbarbaro SA, Wibbelt G, Düx A, Kouakou V, Bokelmann M, Hansen-Kant K, Kirchoff N, Laue M, Kromarek N, Lander A, Vogel U, Wahlbrink A, Wozniak DM, Scott DP, Prescott JB, Schaade L, Couacy-Hymann E, Kurth A. 2024. Selective replication and vertical transmission of Ebola virus in experimentally infected Angolan free-tailed bats. Nat Commun 15:925. https://doi.org/10.1038/s41467-024-45.... 📄 World Health Organization. 2026. Ebola disease caused by Bundibugyo virus — Democratic Republic of the Congo. Disease Outbreak News, 8 October 2026. World Health Organization, Geneva, Switzerland. Alan F. Yoshiaki Matsushita é Doutor em Química Minhas redes sociais:   / yoshicomciencia