An Introduction to Hemophagocytic Lymphohistiocytosis (HLH) | Investigating HLH Podcast

Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH), advances in clinical understanding, and why recognition of this rare hyperinflammatory syndrome remains important. Topics include HLH disease awareness, primary and secondary HLH context, clinical recognition, and the evolving understanding of HLH as a serious hyperinflammatory condition. This video features expert clinician discussion and is intended for US healthcare professionals. 0:00 - What Is Hemophagocytic Lymphohistiocytosis (HLH)? 2:19 - How Clinical Understanding of HLH Has Evolved 6:46 - Immune Dysregulation and Hyperinflammation in HLH 10:16 - Interferon Gamma (IFNγ) and Proinflammatory Cytokines in HLH 14:29 - Primary vs Secondary Hemophagocytic Lymphohistiocytosis (HLH) 21:00 - Key Takeaways for HLH Recognition